|  Accomplia
Accomplia® / Rimonabant affects the Endocannabinoid system, which with the energy homeostasis, which fat storage and the lipid and glucose metabolism play a crucial role. Endocannabinoide work Professor Dr. rer. in the nervous system such as neurotransmitters, peripheral like local of hormones, so nat. Beat Lutz by Institut for physiological chemistry of the Johannes Gutenberg university Mainz. Endocannobinoide do not have anything in common with Cannabis in the composition, them are fatty acid descendants. However Endocannabinoide and THC (Cannabis active substance Tetra hydraulic Cannabinol) bind to the same receptor Cannabinoid receptor CB1. Which role plays the Endocannabinoid system in our physiology, Lutz illustrates descriptive with the terms „eases, rests, forgotten, protects and eats “- thus an body-own recovery and relaxation system, which hold humans in balance. It is, humans stresses it in the oversize.
The CB-receptors, to which Endocannabinoide bind, become in the fatty tissue, in muscles, which exprimiert liver as well as in the brain regions Nucleus accumbens and hypothalami. The latters are to be eaten responsible for the motivation and the appetite. With an offer in excess at food and thus a over activation of the Endocannabonoid system an increased hunger feeling and fat accumulation has as a consequence. This again finally leads to the Dyslipidämie, insulin resistance, a pathological glucose tolerance and in the consequence to diabetes mellitus. In addition sezerniert in the Adipozyten strengthens Inflammationsmarker such as IL-6, PAI-1 and CRP. These can be regarded beside established the already (hypertonia, smoking, high LDL) as new factors of risk for cardiovascular illnesses, so Professor Nickenig.
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